Astragalus membranaceus, ibyatsi bimera mumuryango wa Leguminosae, ikoresha umuzi wumye nkibikoresho byimiti. Mu buvuzi gakondo bw'Abashinwa (TCM), imikorere yacyo nyamukuru ni "toni Qi no gushimangira hanze," kandi ikoreshwa cyane mu bimenyetso nko kubura Qi, umunaniro, kubira ibyuya bidatinze, kubira ibyuya nijoro, no kwanduza indwara ziterwa na virusi. Igitekerezo cya"Qi"muri TCM nigitekerezo kidafatika, igice cyacyo gihuzagurika cyane cyane nubuvuzi bwa kijyambere buvuga"ubudahangarwa." Astragalus polysaccharide.
Mu 2023, Komisiyo y’ubuzima y’Ubushinwa yasohoye Itangazo No . 9, yemeza ko Astragalus, Codonopsis, n’ibindi bikoresho birindwi bigomba gushyirwa ku rutonde rw’ibintu bisanzwe bikoreshwa nk'ibiribwa n'ubuvuzi, bityo bikagura ibyifuzo byabo.
(Inkomoko y’ishusho: Komisiyo y’ubuzima y’igihugu cya Repubulika y’Ubushinwa)
Nubwo Astragalus polysaccharide (APS) aribintu byingenzi bigize Astragalus, amara yumuntu ntabura imisemburo yigifu ikenerwa kugirango hydrolyze itaziguye nka polysaccharide. APS ya macromolecular yabonetse hakoreshejwe uburyo busanzwe bwo kuvoma ntibishobora guhita byambuka epitelium yo munda, bikavamo gukora neza cyane. Agace gato gusa kinjira muri sisitemu, niyo mpamvu nyamukuru yo kubaho kwa bioavailable.
Iterambere - Gusembura imiti gakondo y'Ubushinwa
Bitewe no kwinjirira kwinshi, Astragalus polysaccharide ahanini iguma mumara. Ibigezweho byingenzi byerekana ko APS yitwara cyane nkubwoko bwihariye bwaprebiotic. Ingaruka zabo ntabwo zishingiyegutwarwa, ahubwogusemburwa. APS ikora nka substrate ya mikorobe yo mu nda, APS ikoreshwa na bagiteri zifite akamaro, bityo bikazamura bioavailable [2].
Microbial fermentation yibikoresho byimiti yubushinwa byerekana "korohereza ubwenge gakondo." Uburyo bwo gutunganya amateka bwakoresheje mikorobe kamere ikorana n’ibimera kugira ngo igere ku ntego yo "kugabanya uburozi, kongera imbaraga, no guhindura imiti." Muri rusange, iyi nzira iragaragazaimikoranire hagati ya mikorobe ya metabolism hamwe nibigize ibimera. Bitandukanye no gutunganya umubiri gakondo (urugero, guteka, kubara) cyangwa gutunganya imiti (urugero, vinegere - gukaranga, vino - gukaranga), fermentation ya mikorobe itanga inyungu eshatu zingenzi:ibintu byoroheje byitwara neza, icyerekezo gikomeye, hamwe nibicuruzwa byinshi bitandukanye.
Microbial Fermentation Yongera Kurenza Absorption
Inzira ya fermentation ikora nkuburyo buhanitse bwambere - igogora. Ubwoko bwa porotiyotike yihariye itanga imisemburo "yomeka" hejuru - molekuline - uburemere APS mubice bikurikiranye - molekile - uburemere bwa polysaccharide. Inyungu zihuse ziyi mpinduka ni akwiyongera cyane mu kwinjiza, gushoboza ibice bikora kugirango byinjire muri sisitemu neza.
Nyamara, inyungu za fermentation zirenze kure gufata neza. Ubushakashatsi bwerekana ko ibyo bice - molekuline - ibice byuburemere byakozwe na fermentation ya mikorobe mubyukuri aribyoibimenyetso by'ingenzi byo gukingira indwara. Ugereranije na macromolecular APS kavukire, uduce duto dufite ubudahangarwa burenze - imbuga zo kumenyekanisha hamwe na bioactivite yongerewe imbaraga. Basobanura neza imikorere ya macrophage, T lymphocytes T, hamwe nizindi selile zikomeye z'umubiri, bityo bakagaragaza ingaruka zidasanzwe muguhindura homeostasis yubudahangarwa no kongera ubushobozi bwo kwirwanaho [3].
Ubushakashatsi bwinshi bwerekana buri gihehasi - molekulari - uburemere polysaccharide muri rusange yerekana ibikorwa bikomeye byo gukingira indwara. Urugero:
Hasi - molekuline - uburemere bwa ginseng polysaccharide (10.2 kDa) yerekana imbaraga za macrophage ugereranije na - molekulari - bagenzi babo bafite uburemere (21.3 kDa) [4];
Hasi - molekulari - uburemere glycyrrhiza polysaccharide (GP) bigira ingaruka nziza kumubiri wo mu nda [5];
Ibindi bikingira indwara ya polysaccharide iva mubihumyo,Pueraria lobata, kandi amasoko asa nayo yerekana ibikorwa byiza muri molekuline yihariye - uburemere [6].
Hamwe na hamwe, ibisubizo byashimangiye iuruhare nyamukuru rwa molekile - kugabanya ibiromukuzamura ubudahangarwa bw'umubiri wa polysaccharide.
