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Ibisobanuro ku bicuruzwa

Ibinyomoro byirabura biva mu mbuto zumye zikuze za Piper nigrum L. hifashishijwe ikoranabuhanga rigezweho ryo kuvoma, rikungahaye kuri piperine hamwe nibindi bintu bifatika. Ibikuramo ni umuhondo wijimye wijimye kugeza ifu yera, idafite - cake, hamwe nimpumuro nziza iranga impumuro yumukara kandi nta mpumuro -. Irashobora gushonga mumashanyarazi nka Ethanol na methanol, hamwe nubushobozi buke mumazi. Igisubizo cyavuyeho kirasobanutse, nta mvura ihambaye, yujuje ibisabwa kugirango ubone ibisubizo bitandukanye. Iyo bibitswe mubihe bisabwa (bikonje, byumye, urumuri - gihamya, bifunze), ibicuruzwa bikomeza guhagarara neza mumezi 24 hamwe nibitari munsi ya 5% muburyo bwa piperine, byemeza ubuziranenge buhoraho. Umusaruro ukurikiza ibipimo bya GMP hamwe na 12 bigenzura ubuziranenge, harimo kumenya ibikoresho fatizo, gusuzuma ibyuma biremereye, gupima mikorobe, mugukurikirana inzira - gukurikirana, gusesengura ibintu bifatika, no gupima ibisigazwa bya solide. Ibi birinda umutekano, ubuziranenge, nubushobozi bukoreshwa mubiribwa, inyongera zimirire, kwisiga, hamwe na farumasi.

Isesengura rya tekiniki

1. Ikoranabuhanga ryo gukuramo

Ibikururwa byakozwe hifashishijwe uburyo bwa supercritical CO₂ gukuramo + uburyo bwo kweza molekile:

- Gukuramo COerc Supercritical CO₂ Gukuramo: Koresha CO₂ mubihe bidasanzwe (dogere 35-40, MPa 20-30) kugirango ikuremo ibikorwa bidafite imiti yuburozi. Ubushyuhe buke burinda ubushyuhe - ibyiyumvo byoroshye, bizamura igipimo cyo kugumana piperine kugera kuri 98% (v. ~ 85% na Ethanol gakondo). CO₂ irashobora gukoreshwa, hamwe na 30% yo gukoresha ibikoresho bibisi.

{0} Piperine ikungahaye kuri 40-50% kugeza hejuru ya 95%, hamwe nubuziranenge bwinshi hamwe n’umwanda muke (ivu Ntiri munsi cyangwa iringana na 5%, ubuhehere butarenze cyangwa bungana na 5%).

2. Ibiranga Piperine

- Imiterere ya molekulari: C₁₇H₁₉NO₃, MW 285.34
{0} Itezimbere amara - intungamubiri zishonga (vitamine A, D, E, K, curcumin, astaxanthin). Ubushakashatsi bwerekana ko bwongera curcumin bioavailable inshuro 20.
- Guhagarara: Bihamye hagati ya pH 3–9; munsi ya dogere 121 muminota 30, igihombo kiri munsi cyangwa kingana na 3-5%. Shyushya - gihamye mugutunganya ibiryo. Umucyo - byoroshye, bisaba kubika kure yumucyo.

Kugenzura ubuziranenge

- Ibikoresho bito: Byagenzuwe na Hafi - Infrared Spectroscopy (NIRS) kugirango wirinde gusambana; ICP {2}
{0}
{0} Gusa ibyiciro byujuje byuzuye birekurwa hamwe na COA.

Ibyiza byibicuruzwa

Isuku ryinshi & Igikorwa- Piperine igera kuri 98%, irenze ibisanzwe bisanzwe (60-80%). Igumana bioactivite, ikongerera intungamubiri intungamubiri 15-20%.

Umutekano & Solvent - Ubuntu- Ibiryo gusa - urwego CO₂ rukoreshwa; nta bisigara bifite ubumara. Yujuje GB 2762 (umwanda) na GB 4789 (microbiology).

Ubwiza buhebuje & Guhindagurika- Bihamye munsi ya pH 3–9 na 80–121, bikwiranye no guteka, guhagarika, ibinyobwa, nibindi byinshi. Ifu nziza yifu, byoroshye kuvanga muburyo butandukanye.

Igiciro - Cyiza- Gukuramo neza byongera imikoreshereze yibikoresho 30%. Isuku yo hejuru isobanura dosiye ikenewe, kugabanya ibiciro byo hasi.

Kubahiriza amabwiriza- Yakozwe munsi ya ISO 9001, ISO 22000, na GMP. Itanga COA, icya gatatu - raporo y'ibizamini by'ishyaka, hamwe n'impushya zo gukora zo gutanga amabwiriza.

Porogaramu

Inganda zikora ibiribwa

{0} Yongera kwinjiza amavuta - vitamine zishonga. Umubare: 0.1–0.5%.

- Ibinyobwa bikomeye & Gusimbuza amafunguro: Kunoza uburyohe no kongera kwinjiza poroteyine, fibre, nintungamubiri. Umubare: 0.2–0.8%.

Ibiryo byokurya

{0} Ikoreshwa: 0.5-2%.

Management {0} Management Gucunga ibiro: Kubuza lipase, kugabanya kwinjiza ibinure, byongera metabolism. Akenshi uhujwe nicyayi kibisi, L - karnitine. Ikoreshwa: 1-3%.

Amavuta yo kwisiga

Care {0} Care Kwita ku ruhu: Igikorwa cya Antioxydeant (Kurenza cyangwa bingana na 70% DPPH radical scavenging). Irinda kwangirika kwa UV, gutinda gusaza kwuruhu. Bikwiranye na cream, amavuta yo kwisiga, serumu. Umubare: 0.05–0.2%.

Care 0} Umubare: 0.1–0.3%.

Imiti

. Kugabanya ibipimo n'ingaruka. Mubisanzwe wongeyeho 5-10% byimiti.

- Ubuvuzi bwa Adjunct: Yerekana imiti igabanya ubukana -. Ibishobora gukoreshwa muri arthrite no gufata imiti igabanya ububabare.