1. Ibiranga Ibimera & Agaciro gakondo
Polygonatum (Polygonatum sibiricum cyangwa P. kingianum), yubahwa nka "Icyatsi cyo kudapfa" mu buvuzi gakondo bw'Abashinwa (TCM), ikubiyemo:
Polysaccharide (15-30%): Ibice bigize immunomodulatory
Saponine (Kingianoside A - G): Kurwanya - umunaniro bioactive compound
Homoisoflavonoids: Phytoestrogene - nkabashinzwe kugenzura
2. Ibyingenzi Byibanze & Mechanism
2.1 Kurwanya - Inzira zishaje
2.2 Ibyingenzi Bioactives & Intego
|
Ibigize |
Ibirimo |
Urwego |
Ingaruka zo kwa Clinique |
|
Polysaccharide |
15-30% |
Guhindura inzira TLR4 / NF - κB inzira |
Kugabanya senescence - ibintu bifitanye isano no gutwika |
|
Kingianoside D. |
0.5-1.2% |
Gukora inzira yingufu za AMPK |
Itezimbere kwihangana |
|
Polygonatumin A. |
0.3-0.8% |
Ikangura Nrf2 antioxydeant inzira |
Yongera glutathione kurwego rwa 40% |
3. Ibipimo byemewe byo kwemeza
3.1 Kwemeza
Ibiranga morfologiya: Ibice bihinduranya byerekana imitsi y'amaraso
Urutoki rwa Chromatografique: Ugomba kwerekana impinga 7 ziranga
Kode ya ADN: Ubwoko bwo kugenzura hakoreshejwe matK ikurikirana
3.2 Ibipimo bigezweho
Pharmacopoeia y'Ubushinwa: Polysaccharide Iruta cyangwa ingana na 25%
USP: Ibyuma byose biremereye<10ppm
Ibipimo by’Uburayi: Ibisigisigi byica udukoko<0.01ppm
4. Ibimenyetso bya Clinical
4.1 Kurwanya - Gusaba
Immunosenescence: 1g / kumunsi byongereye ibikorwa bya selile ya NK 35% mumasomo ashaje
Gutezimbere ubwenge: Amanota ya MMSE yazamutseho amanota 3.2 nyuma y'amezi 6
4.2 Inkunga ya Metabolic
Diyabete: Kugabanya glucose yo kwiyiriza 1.8mmol / L (CGM - yagenzuwe)
Umunaniro wa Adrenal: Injyana ya cortisol isanzwe muri 67% yabakoresha
5. Porotokole ikoreshwa neza
5.1 Gukomatanya
Hamwe na Ganoderma: Yongera ubudahangarwa bw'umubiri
Wongeyeho Astragalus: Ikirenga Qi - ingaruka zerekana
Hamwe na Schisandra: Itezimbere imihindagurikire y'ikirere
5.2
Indwara ya Autoimmune: Ibishobora gukingira indwara birenze urugero
Estrogene - ibintu byoroshye: Icyitonderwa gisabwa (kirimo phytoestrogène)
6. Ibiranga ibicuruzwa byiza
Ibimenyetso byukuri:
Ishamba - ryasaruwe muri Sichuan / Western Hubei
Gukuramo kabiri (amazi + 30% Ethanol)
Icya gatatu - igeragezwa ryibikorwa bya telomerase
Ingaruka zo gusambana:
Kwivanga na Disporopsis rhizomes
Gukora polysaccharide
7. Gukata - Ubushakashatsi
Mitophagy induction: Kuraho mitochondriya idakora neza
Gutera - ubwonko bw'ubwonko: Yongera Bifidobacterium yabaturage
Porogaramu y'ingenzi: Bitera synthesis ya kolagen
Umwanzuro wa siyansi
Polygonatum ikuramogatatu - ibikorwa bishya:
1️⃣ Kuvugurura ingirabuzimafatizo(kubungabunga telomere + kugurisha mitochondrial)
2️⃣ Impirimbanyi(immun - metabolike - ubwumvikane bwa endocrine)
3️⃣ Ikinyagihumbi - umutekano wagaragaye(2000+ imyaka muri TCM)
