1. Indangamuntu
Oleuropein ni asecoiridoid glycosideidasanzwe iboneka muri:
Amababi ya elayo (6-9%)
Amavuta yumwelayo adasanzwe (cyane cyane kare - gusarura)
Epidermis y'imbuto za elayo
Ibifenolikeibice bisobanuraUbururukuramba kuramba kugaragara mubaturage ba Mediterane.
2. Inshuro eshatu - Uburyo bukoreshwa
Ingaruka z'umutima:
Gutezimbereibikorwa bya eNOS(300% OYA nta mbaraga)
KamereInhibitor(angiotensin kuziba)
Ubuhanga bwa Mitochondrial:
AMPK fosifora ↑ 150%
Igikorwa cya I / III gukora neza +35%
Epigenetike Guhindura:
Imvugo ya SIRT1 ↑ 2.1-inshuro
NF - κB guhagarika (IL-6 ↓ 60%)
3. Ibipimo bya Zahabu
Kwemeza Porotokole:
HPLC - PAPAkuri oleuropein aglycone
NMRkwemeza imiterere ya molekile
LC - MS / MS purity verification (>98%)
Ibintu bihamye:
pH 5.2-6.8 ibisubizo byamazi
Avoid >Gutunganya impamyabumenyi 60
Gupakira ibirahuri byijimye ni ngombwa
4. Imiti ya farumasi
Sisitemu yo Gutanga Ibishya:
Cyclodextrin(gukemura amazi ↑ 900%)
Amashanyarazi(Kurekurwa amasaha 72)
Sublingual nanoemulsions(Tmax<15min)
Inzira ya Metabolite:
Hydroxytyrosol (ifishi ikora)
→ Oleacein (anti - inflammatory)
Acide Acide ya Elenolike (antimicrobial)
