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Ibisobanuro ku bicuruzwa

1. Ibiranga ibicuruzwa

Ibyingenzi byingenzi:

Paeoniflorin (Birarenze cyangwa bingana na 40%): Core anti - inflammatory na neuroprotective agent

Monoterpene Glycoside Yose (Iruta cyangwa ingana na 80%): Harimo oxypaeoniflorin, benzoylpaeoniflorin

Polifenol: Acide Gallic, aside ellagic (antioxydeant)

Polysaccharide (5-10%): Imikorere yo gukingira indwara

Inkomoko y'ibimera: Imizi yumye ya Paeonia lactiflora Pall. (Ranunculaceae)

Ibintu bifatika: Kureka - cyera kugeza ifu yijimye yijimye, isharira gato, amazi - gushonga

Ibisobanuro:

Ibyuma biremereye (Pb, Cd, As)<5ppm

Ibisigisigi byica udukoko byujuje CP2020

Umubare wa HPLC wa paeoniflorine (RSD<2%)

Umwirondoro

Ibicuruzwa bisanzwe byabonetse binyuze munsi - ubushyuhe bwo gukuramo ubushyuhe bwo gukuramo, burimo:

Imikorere itatu yibanze:

Kurwanya - Gutwika & Analgesic:

Kubuza COX-2 (IC 50=3.2 μM)

Kugabanya urwego rwa TNF - / IL-6 (mubuvuzi ↓ 35%)

Neuroprotection:

Gukora inzira ya BDNF (itezimbere guhangayika / kwiheba)

Kugabanuka - amyloide yoherejwe (ikora neza muri moderi ya Alzheimer)

Amabwiriza y'abagore:

Igabanya dysmenorrhea yibanze (50% scores amanota ya VAS)

Guhindura reseptor ya estrogene (ER - / impirimbanyi)

Ibyiza vs NSAIDs:
✓ Nta kurakara kwa GI (kubika COX-1)
Dual Dual - icyerekezo cyo kwirinda indwara (Th1 / Th2 impirimbanyi)
Ograp Monografiya muri Pharmacopoeia yubushinwa (CP) na Pharmacopoeia yu Buyapani (JP)

Isesengura rya tekiniki

Inzira	Udushya twinshi	QC Ibipimo
Hasi - gukuramo ubushyuhe bukabije	Kurinda ibice bya termolabile (<45°C)	UPLC - QTOF yuzuye - urutoki
Molecular icapura kweza	Paeoniflorin purity >95%	Kumenya UV (λ =230 nm)
Imvura igwa ya polysaccharide	Ikungahaza 10-50kDa ibice bikora	Fenol - acide sulfurike
Koresha - microencapsulation yumye	Kugabanya hygroscopicity (ubushuhe<5%)	Amezi 36 yihutishije igeragezwa ryumutekano